IDF21-0423 Michigan neuropathy screening for assessing diabetes in participants and correlation to the immune response

Background: Diabetes Mellitus (DM) as a chronic disease makes some influence to all organic systems in the body. Some of these changes affect nervous system (different kinds neuropathies), and kind immune response disorders could be expected. Michigan Neuropathy Screening Instrument (MNSI) is used assess distal symmetrical peripheral neuropathy DM. Aim: This research study aimed population diabetic patients with MNSI check duration DM on response. Inflammatory markers (CRP; Le; SE) cytokines (IL-6, Il-1β, TNF-α, TGF-β) were measure Method: The included 100 participants type 2 (men women) 30 healthy control group. All examined through regular examination General Hospital Tešanj, BiH. divided into 3 groups, by criteria DMT2 first group 32 less than 10 years (group A); second 35 10-20 B) third 33 more 20 C). participants. status distribution groups (sensitivity 93.3%, specificity 25%). Cut-off values were: ≤2.5 points without neuropathy; 2.5-7- I stage, ≥7.5 stage II. ELISA test was performed for measurement cytokines. Results: results have shown that: 7 had ≤2.5; 31 2.5-7 p, 54 ≥7.5. Groups A (n=4) B (n=3) similar number neuropathy. (n=22) C (n=20) II No significant difference between found. Statistically correlations found IL-6 (R=0.402, p=0.025); CRP (R=0.784, p=0.0001); (R=0.500, p=0.034). statistically inflammatory markers. Also, not HbA1C MNSI, Discussion: Previous studies conducted impact hyperglycemia environment body, positive correlation. However, there no that measured different periods processes. unique because score showed correlation only duration. an increase across according other cytokines, especially TGF-β1, Subsequent should look at effect drugs which treat glycaemia concomitant diseases.